Tiredness, headache, and muscle/joint aches WITH loss of taste/smell.Tiredness, headache, and muscle/joint aches without loss of taste/smell.The four clinically distinct symptom presentation groups researchers identified are: But using a statistical modeling approach called “latent class analysis” that helps uncover hidden clusters in huge data sets, researchers were able to identify more clearly differentiated symptom presentations among those who reported more persistent, lingering effects of the illness. Most long COVID studies have focused primarily on the individual symptoms of a few hundred patients without considering clusters of symptoms. This paper, Long COVID Clinical Phenotypes Up to Six Months After Infection Identified by Latent Class Analysis of Self-Reported Symptoms, published in Open Forum Infectious Diseases found that 70% of participants had minimal or no symptoms at three and six months follow-up reporting. Symptom cluster analysis identifies four phenotypes Unlike most long COVID studies that rely predominantly on a retrospective review of information from hospital electronic health records, INSPIRE allows for ongoing interaction with participants to better document the evolution of symptoms. The nearly 6,000 participants - including a comparative group who visited health care facilities with COVID-like symptoms but tested negative for the virus - began self-reporting symptom data via detailed surveys beginning in December 2020 and followed for up to 18 months. INSPIRE is a federally funded collaboration of eight major academic medical centers seeking to better understand the long-term effects of COVID. “While it is becoming increasingly clear that long COVID is not a singular condition, having data showing several distinct, symptom-defined phenotypes is a strong step towards developing evidence-driven approaches to treat the millions of people who continue to experience lingering symptoms,” said Gottlieb, an emergency medicine physician and researcher at RUSH University Medical Center. Lead author Michael Gottlieb, MD, says this better understanding of the clinically distinct manner that patients experience post-COVID -19 complications is an important step toward both patients and clinicians being able to better identify and manage persistent, post-COVID 19 symptoms. The INSPIRE study data identifies four clinically distinct sets of symptoms - or phenotypes - in nearly 6,000 participants. Ann & Robert H.The latest data from a nationwide study assessing long-term COVID-19 adds to the growing body of evidence that long COVID is not a single condition.Illinois – My Chart Provider Account Login Page
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